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GHK-Cu (copper(II) glycyl-L-histidyl-L-lysine) is one of the more structurally interesting naturally occurring peptide-metal complexes. Unlike many research peptides that are purely organic molecules, GHK-Cu is an organometallic complex — a tripeptide that chelates a divalent copper ion as an integral part of its active structure. Understanding how this chelation works, and why the resulting geometry…
GHK-Cu is a naturally occurring copper-binding tripeptide consisting of glycine, histidine, and lysine (Gly-His-Lys), complexed with a copper(II) ion. It was first isolated from human plasma in 1973 and has since been identified in multiple biological contexts, including saliva, urine, and the breakdown products of collagen. GHK-Cu has accumulated one of the most extensive research…